T-box genes in early embryogenesis

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Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis

T-box genes are conserved in all animal species. We have identified two members of the T-box gene family from the zebrafish, Danio rerio. Zf-tbr1 and zf-tbx3 share high amino acid identity with human, murine, chick and Xenopus orthologs and are expressed in specific regions during zebrafish development.

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T-box genes in human disorders.

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The myriad developmental roles served by the T-box family of transcription factor genes defy easy categorization. Present in all metazoans, the T-box genes are involved in early embryonic cell fate decisions, regulation of the development of extraembryonic structures, embryonic patterning, and many aspects of organogenesis. They are unusual in displaying dosage sensitivity in most instances. In...

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Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis

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ژورنال

عنوان ژورنال: Developmental Dynamics

سال: 2003

ISSN: 1058-8388,1097-0177

DOI: 10.1002/dvdy.10480